Amanda Seyfried has revealed she was left stunned by an aggressive confrontation with Elizabeth Holmes's partner, Billy Evans, while filming a documentary in which she unexpectedly reprised her portrayal of the disgraced Theranos founder.

The actress, 40, returned to the role that won her an Emmy for the Hulu drama The Dropout in You Can See Everything, a documentary directed by Nathan Fielder, 43, and Lance Oppenheim, 30.

Speaking publicly about the project for the first time, Amanda described a tense dinner-table exchange with Billy, 33, involving the late conservative activist Charlie Kirk, who died aged 31.

In an interview with Rolling Stone, Amanda said: "There was no reason for him to get that aggressive."

She added: "That's the word I'm going to use, as it's more diplomatic. If my jaw wasn't obviously on the floor, you could tell, like, it had come unhinged."

The confrontation occurred during one of several reconstructed scenes featuring Amanda as Elizabeth, 42, whose blood-testing company Theranos collapsed after its claims about revolutionary medical technology were exposed as misleading.

The documentary combines footage of Elizabeth filmed before she began serving her prison sentence with dramatised sequences featuring Amanda, who previously played the former Silicon Valley entrepreneur in the acclaimed 2022 television miniseries.

Describing her reaction to Billy's behaviour during the exchange, Amanda said: "I don't want to provoke him, but at this point, it's kind of like, the gloves are off. Because this guy has disrespected me in such a way that I was like, 'Oh, I don't think so, buddy'."

Amanda also revealed she agreed to begin filming with Nathan before consulting her professional representatives about the project.

She said she had "no creative control" over the finished documentary, despite her prominent role in its second half.

The actress nevertheless insisted she remained pleased with her decision to participate.

She said: "I don't regret it at all. I'm having the time of my life right now!"

Amanda's appearance was reportedly kept secret before the documentary's release, with early audiences discovering her involvement only when the film reached its dramatised sequences.

The actress became closely associated with Elizabeth after starring in The Dropout, which chronicled the rise and collapse of Theranos and the deception surrounding its blood-testing technology.

Her performance earned her the Emmy for outstanding lead actress in a limited or anthology series or movie in 2022.

Amanda first achieved international recognition as Karen Smith in the 2004 comedy Mean Girls, alongside Lindsay Lohan, 40, and Rachel McAdams, 47.

She subsequently appeared in the musical films Mamma Mia! and Mamma Mia! Here We Go Again, as well as Les Misérables and David Fincher's Mank, for which she received an Academy Award nomination for best supporting actress.

Her more recent television work includes the psychological thriller The Crowded Room, while her film credits also include the 2025 thriller The Housemaid, opposite Sydney Sweeney, 29.

According to the account of You Can See Everything, Nathan and Lance filmed Elizabeth during the 34 days preceding the start of her prison sentence, with that footage forming the documentary's opening half.

Amanda then appears in reconstructed scenes during the second half, including the confrontation with Billy.

The documentary has generated considerable awards attention, with speculation about potential Academy Award nominations for both the film and Amanda's performance.

Reports surrounding its release have also claimed box-office takings exceeding $80 million and five wins at the Critics' Choice Documentary Awards, including best documentary feature.

Elizabeth was convicted in January 2022 on four counts relating to fraud against investors in Theranos, the healthcare company she founded and promoted as a revolutionary development in medical testing.

Theranos claimed its technology could perform numerous diagnostic tests using a tiny blood sample collected through a finger prick.

Investigations by The Wall Street Journal raised serious questions about the reliability of its technology and the accuracy of the company's claims, contributing to the collapse of the business.

Elizabeth was sentenced to more than 11 years in prison in November 2022 and began serving her sentence in May 2023.

The case subsequently became the subject of books, podcasts and screen adaptations, including The Dropout, which also featured Naveen Andrews, 57, as former Theranos president and chief operating officer Sunny Balwani.

Balwani was separately convicted of fraud-related offences arising from his involvement in the company.