With Gurley and Brown at home, Henderson, second-year pro John Kelly and third-year pro Justin Davis were scheduled to share the workload Saturday.
The 5-foot-8, 208-pound Henderson got the majority of his in the first quarter.
That was expected after he came off the bench and had for 13 yards in six carries against the Raiders.
Henderson said he was not nervous before his first game.
"I had already had my mind right," he said. "It's football. ... That guy across from you, he's going to try to knock your head off, so you've got to be ready to knock his head off. You got to be locked in, and I was locked in."
During his junior season at Memphis, Henderson averaged nearly nine yards per carry and rushed for 1,909 yards and 22 touchdowns. He caught 19 passes, three for touchdowns.
Henderson struggled at times with alignment against the Raiders, but McVay said last week that Henderson showed during joint practices and the game that he can be tough to bring down.
"When you do see the ball in his hands he's physical," McVay said. "It seemed like a play's blocked for about four or five 1/8yards3/8 and then it ends up being second-down and three."
Henderson said that Gurley and all of the running backs have helped him make the transition from college to the NFL.
The main advice for Henderson and younger backs is centered on pass protection, Gurley said.