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There is no single 'gay gene,' DNA analysis of nearly half a million people shows

Amina Khan, Los Angeles Times on

Published in Science & Technology News

A new study that analyzed the DNA of nearly half a million people has found that while genetic differences play a significant role in sexual preference, there is no single gene responsible.

The findings, described Thursday in the journal Science, looked at sexual behavior and not sexual identity. Still, the results debunk the idea of a so-called singular "gay gene," call into question such sexual orientation frameworks as the Kinsey scale -- and hint at the complex factors that influence human sexuality, including society and the environment.

"The findings themselves reinforce this idea that diversity of sexual behavior across humanity is really a natural part of our overall diversity as a species," said Benjamin Neale, a geneticist at the Broad Institute of the Massachusetts Institute of Technology and Harvard and one of the study's senior authors. "That's a really meaningful and important result."

While estimates of same-sex experiences vary, a 2016 CDC study found that 6.2% of men and 17.4% of women between the ages of 18 to 44 in the U.S. reported at least one same-sex experience in their lifetimes. A smaller portion, 1.3% of women and 1.9% of men, identified as lesbian or gay, and 5.5% of women and 2.0% of men said they were bisexual -- underscoring the difference between sexual behavior and sexual orientation identity.

Scientists have long probed the nature of same-sex behavior, finding some evidence in twin studies that genetics plays a role. But such research has been typically involved small numbers of people, and it hasn't used modern methods of genomic analysis, scientists said.

"I had seen some quite poor studies of small samples and false claims and things, so I was glad that finally this topic was examined in a very scientific way with a large sample," said Melinda Mills, a social and molecular geneticist at the University of Oxford who was not involved in the work.

 

Neale and an international team of researchers performed what's known as a genome-wide association study. Using this method, scientists use statistical methods to search for connections between SNPs -- single nucleotide polymorphisms, or individual differences in a single building block in the genetic code -- and a particular trait.

Finding clear and verifiable patterns in that genetic data requires a huge sample, and the scientists knew where to find it. They pulled 408,995 individual records from the UK Biobank as well as 68,527 records from the U.S.-based personal genomics company 23andMe. This gave them an overall sample size of 477,522 people, 26,827 of whom reported same-sex sexual behavior.

The researchers found two significant spots in the genome that were linked to same-sex behavior across people of both sexes. And when they analyzed male and female genomes separately, they found three more -- two specifically for men and one specifically for women -- bringing the total number of significant genetic markers up to five.

Nonetheless, when taken altogether, these five locations on the genome could account for much less than 1% of same-sex sexual behavior on a population level, the researchers said.

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