Marin Cilic, seeded sixth, put out American Ryan Harrison 7-6 (7-4), 6-4, 7-6 (7-4); Aussie Nick Kyrgios lived up to potential with a defeat of 15th seed Jo-Wilfried Tsonga 7-6 (7-5), 4-6, 7-6 (8-6), 7-6 (7-5).
Spanish 10th seed Pablo Carreno Busta advanced past Gilles Muller 7-6 (7-4), 4-6, 7-5, 7-5 in the heat of the day.
Briton Kyle Edmund reached the fourth round for the first time. Edmund spent just over three and a half hours in defeating Georgian Nikoloz Basilashvili 7-6 (7-0), 3-6, 4-6, 6-0, 7-5.
The Bahamas-based Brit, who trains at a facility affiliated with Lleyton Hewitt, broke through with 70 winners and 20 aces.
A 17th double-fault from Basilashvili gave Edmund a match point, which he converted as his opponent drove a return into the net.
"Mostly, I'm a bit tired, but it was really good to win a match like that in tough conditions," Edmund said. "It was another five-set win for me, which is good."
Edmund, who broke seven times from 27 chances, duplicated his best Grand Slam showing after also reaching the fourth round at the 2016 US Open.
In the women's draw, fourth seed Elina Svitolina ended the dream run of 15-year-old fellow Ukrainian qualifier Marta Kostyuk 6-2, 6-2 -- with the poised youngster assured of a bright future in the sport.
"How much you have to pay Svitolina to have one-hour lesson -- I got it for free," Kostyuk joked. "I learned that I can play against everyone.
"But she's a god. I cannot do anything against her, that's the problem."
Croatian Petra Martic put out Lusika Kumkhum 6-3, 3-6, 7-5 two days after the Thai qualifier eliminated Swiss Belinda Bencic.
Czech Denise Allertova beat Magda Linette of Poland 6-1, 6-4. Belgian Els Mertens converted on a fourth match point to edge France's Alize Cornet 7-5, 6-4 and reach the second week of a Grand Slam for the first time in her career.
Cornet was treated for heat illness stretched out on the court, with ice bags failing to arrive on time when requested by the trainer.
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