Obvious starters: DeMarco Murray (Titans), Delanie Walker (Titans), Jay Ajayi (Dolphins).
Who to start: Even if Tennessee is forced to start Matt Cassel, Rishard Matthews (Titans) should be able to take advantage of Miami's shoddy secondary, earning flex value with WR3 upside. Jarvis Landry (Dolphins) is once again a PPR stud -- he's on pace for 133 receptions -- and DeVante Parker (Dolphins) is on pace for 1,227 receiving yards, mostly thanks to garbage time production. Both are solid WR2 options.
Who to sit: Marcus Mariota (Titans) is a coin flip to start this week, plus hamstrings are notoriously easy to re-injure. Dip into the quarterback streaming pool. Sadly, Derrick Henry (Titans) is still an underutilized insurance policy. Jay Cutler (Dolphins) is another poor performance away from potentially being benched.
Sleeper: Third on Tennessee in targets, it's only a matter of time before Eric Decker (Titans) finds the end zone.
L.A. CHARGERS AT N.Y. GIANTS
Obvious starters: Melvin Gordon (Chargers), Keenan Allen (Chargers).
Who to start: Philip Rivers (Chargers) has thrown for three touchdowns in each of his previous two starts against the G-Men. Tyrell Williams (Chargers) deserves PPR flex recognition this week. The Giants can't cover tight ends -- they've allowed five touchdowns in four games to the position -- giving both Hunter Henry (Chargers) and Antonio Gates (Chargers) value this week. Eli Manning (Giants) is a borderline QB1. You'll start Odell Beckham (Giants) if he's available, but make sure to monitor his injuries (finger, ankle). Sterling Shepard (Giants) and Evan Engram (Giants) have proven valuable in PPR leagues. Engram is a borderline TE1.
Who to sit: Deep-threat Travis Benjamin (Chargers) is only a flex option if you're desperate enough. Otherwise, he's too inconsistent. The Giants D/ST is operating on reputation only. Brandon Marshall (Giants) is dealing with a toe injury that could limit him.
Sleeper: Paul Perkins (ribs) and Orleans Darkwa (back) are both ailing, while rookie running back Wayne Gallman (Giants) filled in nicely against the Buccaneers. Another solid performance could help him lock down the gig full-time.
ARIZONA AT PHILADELPHIA
Obvious starters: Larry Fitzgerald (Cardinals), Zach Ertz (Eagles), Alshon Jeffery (Eagles).
Who to start: Carson Palmer (Cardinals) projects nicely against Philadelphia's weak secondary. In three starts against the Eagles, Palmer has averaged 302 passing yards and two scores. Palmer targeted Andre Ellington (Cardinals) 14 times last weekend. That type of workload earns him legit flex consideration in PPR. Carson Wentz (Eagles) has developed into a borderline QB1 and is a perfect streaming option if your quarterback is on a bye this week. LeGarrette Blount (Eagles) is a solid flex play with RB2 upside after three-of-four good games.
Who to sit: It's hard to trust John Brown (Cardinals) considering his health issues. Unfortunately, Brown's presence could cut into Jaron Brown's (Cardinals) targets. There's a chance J.J. Nelson (Cardinals) gets lost in the shuffle as well. Chris Johnson (Cardinals) has yet to do anything worthwhile in his role as lead back. Wendell Smallwood (Eagles) is nursing a knee injury after two productive weeks.
Sleeper: If Smallwood misses the game, Corey Clement (Eagles) will be in line for double-digit touches.
JACKSONVILLE AT PITTSBURGH
Obvious starters: Leonard Fournette (Jaguars), Le'Veon Bell (Steelers), Antonio Brown (Steelers), Steelers D/ST.
Who to start: Vertical threat du jour, Martavis Bryant (Steelers) -- like his QB -- plays better at home.
Who to sit: You can only trust Blake Bortles (Jaguars) if plays on foreign soil. The Jaguars D/ST have had issues against running backs this season. Marqise Lee (Jaguars) and Allen Hurns (Jaguars) are the most desperate of flex plays against a solid Pittsburgh secondary. There are plenty of QBs I'd start over Ben Roethlisberger (Steelers) this week, but if you're desperate, he's a streaming option.
Sleeper: Rookie wideout Juju Smith-Schuster (Steelers) has surpassed Eli Rogers for Pittsburgh's slot position. If Jacksonville focuses on Brown and Bryant, the rook could have a big day.
BALTIMORE AT OAKLAND
Obvious starters: None.
Who to start: The Ravens D/ST is a solid matchup play in EJ Manuel's first start. Javorius Allen (Ravens) has had at least five catches in three straight games, supporting flex play in most PPR leagues. Jared Cook (Raiders) is a borderline TE1 against a Baltimore defense that has allowed tight ends to score four touchdowns in four games.
Who to sit: Baltimore's passing game is simply too conservative for me to recommend any of the principals -- Joe Flacco (Ravens), Jeremy Maclin (Ravens) and Mike Wallace (Ravens). I'm downgrading the entire Oakland offense with EJ Manuel (Raiders) under center, with one exception.
Sleeper: Despite losing two fumbles the past three weeks, Alex Collins (Ravens) is expected to receive more playing time due to his play-making ability, something that is lacking in the Baltimore offense.
SEATTLE AT L.A. RAMS
Obvious starters: Russell Wilson (Seahawks), Doug Baldwin (Seahawks), Jimmy Graham (Seahawks), Seahawks D/ST, Todd Gurley (Rams), Sammy Watkins (Rams).
Who to start: Cooper Kupp (Rams) is Los Angeles' best underneath target, making him a good flex option in PPR leagues.
Who to sit: Seattle's running back situation is back to being muddled so stay away from Eddie Lacy (Seahawks), Thomas Rawls (Seahawks) or C.J. Prosise (Seahawks) until we have a clue of what they plan on doing going forward. Jared Goff (Rams) is still a streaming option in deeper leagues at best.
Sleeper: Paul Richardson (Seahawks) is second on the team in receiving yards (173) and tied for first with two touchdowns. If Baldwin is still limited by his groin injury, Richardson could have a breakout game.
GREEN BAY AT DALLAS
Obvious starters: Aaron Rodgers (Packers), Jordy Nelson (Packers), Randall Cobb (Packers), Dak Prescott (Cowboys), Ezekiel Elliott (Cowboys).
Who to start: Martellus Bennett (Packers) leads Green Bay with 27 targets. It's a matter of time before the borderline TE1 finds the end zone. Dez Bryant (Cowboys) torched Green Bay in the playoffs last season, catching nine balls for 132 yards and two touchdowns. He's also scored in three of five games he's faced the Packers. Cole Beasley (Cowboys) is still relevant in PPR leagues, especially with bye weeks beginning.
Who to sit: If Davante Adams (Packers) is available, you'll likely start him. I'd give a week or so after the hit he received. Make sure to monitor his advancement through the NFL's concussion protocol. Although both are practicing, I'd stay from injured running backs Ty Montgomery (Packers) and Jamaal Williams (Packers) this week. This is a bad matchup for future Hall of Fame tight end Jason Witten (Cowboys).
Sleeper: Rookie running back Aaron Jones (Packers) is capable of providing RB2 production if he gets the touches Sunday.
KANSAS CITY AT HOUSTON
Obvious starters: Kareem Hunt (Chiefs), Travis Kelce (Chiefs), Chiefs D/ST, DeAndre Hopkins (Texans), Lamar Miller (Texans), Texans D/ST.
Who to start: The tough matchup might lower my expectations, but Alex Smith (Chiefs) is still a top streaming option this week. Deshaun Watson (Texans) is approaching "obvious starter" territory.
Who to sit: I know it's difficult to sit Tyreek Hill (Chiefs) with such a high ceiling, but Houston's secondary has been dominant outside of its performance in New England two weeks ago. Like Hill, the big-play ability of Will Fuller (Texans) normally makes him a lock for your lineup, but this is a terrible matchup.
Sleeper: Kansas City has been hit-or-miss against tight ends this season. Ryan Griffin (Texans) is a top streaming option if your regular tight end is on a bye.
MINNESOTA AT CHICAGO
Obvious starters: Stefon Diggs (Vikings), Vikings D/ST, Jordan Howard (Bears).
Who to start: Sam Bradford (Vikings) is a worthy streaming option against a mediocre Chicago defense. Adam Thielen (Vikings) is a borderline WR2 and could finally find the end zone with Bradford back. Tarik Cohen (Bears) still has RB2 upside in PPR leagues.
Who to sit: Latavius Murray (Vikings) will be touchdown-dependent for fantasy value. Chicago's passing game with Mitchell Trubisky (Bears) is a complete unknown so stay away from Kendall Wright (Bears) and Markus Wheaton (Bears).
Sleeper: Of course, everyone knows rookie QBs and tight ends are mighty fond of one another. Zach Miller (Bears) is a borderline TE1.
(c)2017 The San Diego Union-Tribune
Visit The San Diego Union-Tribune at www.sandiegouniontribune.com
Distributed by Tribune Content Agency, LLC.