Obvious starters: None.
Who to start: Jonathan Stewart (Panthers) and Christian McCaffrey (Panthers) are both flex options with RB2 upside considering their usage -- both will see double-digit touches -- but temper expectations against a very tough Detroit defense. You could do much worse at QB than Matthew Stafford (Lions) at home -- he's thrown 18 touchdowns against only five interceptions in his last 10 games at Ford Field. Carolina's secondary struggles against a short passing game -- it has allowed over 70 percent of short passes to be completed -- meaning both Golden Tate (Lions) and Theo Riddick (Lions) could shine in PPR leagues this week.
Who to sit: You no longer have to worry about dropping Cam Newton (Panthers) after his vintage performance versus the Patriots, but I don't recommend starting him on the road against a very opportunistic secondary. I'd fade a hobbled Kelvin Benjamin (Panthers) and Devin Funchess (Panthers) at receiver as well. This is a difficult matchup to trust a banged up Ameer Abdullah (Lions) -- monitor his ankle injury. It appears Darren Fells (Lions) may have passed Eric Ebron (Lions) on the tight end depth chart. Neither are a good option this week.
Sleeper: The Lions D/ST has quietly turned into a bona fide starting unit in fantasy.
SAN FRANCISCO AT INDIANAPOLIS
Obvious starters: T.Y. Hilton (Colts)
Who to start: Carlos Hyde (49ers) is a top five running back this week if he doesn't have a setback with his hip injury. Pierre Garcon (49ers) leads San Francisco in routes run, targets, receptions and receiving yards, giving him WR2 upside this week. Frank Gore (Colts) gets too many touches for you to sit him, especially in a "revenge" game like this. He has solid flex value with RB2 upside.
Who to sit: There's some upside because Jacoby Brissett (Colts) can make plays with his legs, but he's facing a San Francisco pass rush fresh off a six-sack performance. You simply can't trust Donte Moncrief (Colts) until Andrew Luck returns. Jack Doyle (Colts) is working his way through the NFL's concussion protocol and faces a defense that has only allowed 77 receiving yards on 10 receptions to tight ends in four games.
Sleeper: Brian Hoyer (49ers) has averaged 355 passing yards and two touchdowns his last two starts against Indianapolis. He's a good option if you need to stream quarterback this week.
TENNESSEE AT MIAMI