At Colts (1-3, -1 1/2) over 49ers (0-4), 18-15: Two struggling teams, two struggling quarterbacks, so make it a venue call and hope the least-bad team wins.
At Giants (0-4, -3 1/2) over Chargers (0-4), 27-23: Two of four remaining winless teams. Somebody gotta win! Eli Manning and Philip Rivers should make it entertaining.
At Eagles (3-1, -6 1/2) over Cardinals (2-2), 28-23: The better team is home in this Bird Bowl, but liking Carson Palmer to keep it inside a plump betting line.
At Steelers (3-1, -8 1/2) over Jaguars, 27-16: Le'Veon Bell is really, really good and coming off a breakout game. Jax has league's worst run defense. You do the math.
At Raiders (2-2, -2 1/2) over Ravens (2-2), 19-16: EJ Manuel in for injured Derek Carr is huge QB dropoff for Raiders, but Joe Flacco's struggles will continue vs. this pass rush.
Seahawks (2-2, even) over At Rams, 27-17: Finally, a home team loses! Jared Goff and Todd Gurley lead NFL's top-scoring offense, but Seattle D will have something to say about that.
At Texans (2-2, +1) over Chiefs (4-0), 24-20: Upset! Break out the champagne, '72 Dolphins. The last unbeaten is about to fall. Sunday nighter finds KC on road after a short week, and facing a huge challenge in scintillating Texans rookie QB Deshaun Watson.
Week 5 byes: Broncos, Falcons, Redskins, Saints.
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