vicissitude \vi-SIS-i-tood, -tyood\ (noun) - 1 : A change or variation. The quality of being changeable; mutability. 2 : Often vicissitudes. One of the sudden or unexpected changes or shifts often encountered in one's life, activities, or surroundings.
"As Ronald was quick to point out, everyone of his generation had experienced the vicissitudes of the current century.'"
Latin vicissitudo, from vicissim, in turn, probably from vices, pl. of *vix, change.