Health Advice



Protect yourself from dangerous medication interactions

By Michael Roizen, M.D. and Mehmet Oz, M.D. on

Actress Brittany Murphy died from a drug overdose in 2009. But what many people don't realize is that it was an accident caused by combining legal prescription drugs and over-the-counter medications to help her get through pneumonia: She took acetaminophen and hydrocodone in prescription Vicodin; chlorpheniramine, an OTC antihistamine; and L-methamphetamine, which is in some OTC decongestant inhalers. She also had antibiotics in her system.

Many people don't know that common OTC drugs can become deadly when combined with prescription medications, and it isn't just prescription painkillers that pose a threat.

A study published in the Journal of the American Geriatrics Society illustrates the lack of awareness. The researchers found that many folks who are prescribed apixaban (Eliquis) for atrial fibrillation are unaware that taking some OTC meds along with that drug can be risky. In fact, their survey showed 33% of folks who use the medication also took OTC products daily, such as nonsteroidal anti-inflammatory drugs. And 66% didn't know there was an increased risk of serious bleeding from combining NSAIDs with apixaban.

So here's how to talk to your docs about medication interactions.

-- At every doctor appointment, especially if you see more than one doctor, review your prescription and OTC medications, supplements and herbs you're taking. Make sure each doc knows what others are giving you!

-- Each time you're prescribed a new medication, ask your doctor about contraindications with what you're taking or might occasionally take! That includes laxatives, vitamins, OTC pain and allergy meds, etc.


-- Read package inserts and labels on everything!


Mehmet Oz, M.D. is host of "The Dr. Oz Show," and Mike Roizen, M.D. is Chief Wellness Officer and Chair of Wellness Institute at Cleveland Clinic. To live your healthiest, tune into "The Dr. Oz Show" or visit

(c) 2019 Michael Roizen, M.D. and Mehmet Oz, M.D.

Distributed by King Features Syndicate, Inc.

(c) 2019 Michael Roizen, M.D. and Mehmet Oz, M.D. Distributed by King Features Syndicate, Inc.


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