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Widespread screening for breast cancer didn't do much to save women's lives, study finds

Karen Kaplan, Los Angeles Times on

Published in Health & Fitness

Breast cancer deaths have declined markedly in the Netherlands since a nationwide screening program began in 1989, but mammograms deserve little -- if any -- of the credit, a new study suggests.

In fact, the main effect of inviting Dutch women between the ages of 50 and 74 to get a mammogram every other year has been a steady increase in cases of early-stage breast cancers. More than half of these cancers were harmless and would have gone totally unnoticed if women hadn't had mammograms in the first place, the study authors report.

As more women were invited to join the screening program and the screenings became more high-tech, the overall benefit of those mammograms fell. In what they called the "best case scenario," the researchers calculated that for every woman whose life was saved by a screening mammogram, 16 others were unnecessarily diagnosed with -- and probably treated for -- breast cancer. In their other scenario, none of that wasted treatment was offset by saved lives.

The results were published Tuesday in the BMJ, formerly known as the British Medical Journal.

Screening programs rest on the assumption that cancers caught early are easier to treat than those noticed after they start causing symptoms. But with breast cancer, that may not be the case.

The new study demonstrates why.

 

The authors, from the International Prevention Research Institute in Lyon, France, used Dutch health records to evaluate the country's breast cancer screening program. It began in 1989, when women between the ages of 50 and 69 were asked to get a mammogram once every two years. In 1997, the program was extended to women through age 75. The program got a further boost in 2006, when traditional film-based mammograms were replaced with digital ones.

The screening program was popular, with about 80 percent of Dutch women participating. And at first glance, it seemed to be helping.

In the years 2011 to 2013, 25.8 of every 100,000 Dutch women died of breast cancer. That was 38 percent lower than in the years 1987 to 1989, before the screening program began. The breast cancer death rate fell most for women under the age of 50 (a 45 percent decline), followed by those in their 50s and 60s (a 39 percent decline) and then women ages 70 and up (a 33 percent decline).

That pattern pointed to a "cohort effect" -- a combination of genetic, environmental and lifestyle factors that made breast cancer less deadly over time, the researchers said. Overall, they estimated that this was responsible for about 5 percent of the overall reduction in breast cancer deaths between 1995 and 2012.

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