Researchers believe that CBDA could be the next big medication for treating and maintaining overall mental and physical well-being.
This article originally appeared on Cannabis.net and has been reposted with permission.
Cannabidiolic acid (CBDA) is a minor cannabinoid with significant medicinal promise. Recent research suggests that CBDA could be an alternative treatment for managing or curing inflammation, anxiety, cancer, and seizures. The therapeutic potential of CBDA is the newest discovery of cannabinoid-based drugs. Introduction to CBDA Although research is still in the infant stage, researchers believe that CBDA could be the next big medication for treating and maintaining overall mental and physical well-being. Many cannabis-based scientists are optimistic that CBDA would reduce the need for conventional drugs with long-term side effects.
CBDA is mainly found in cannabis plant material. Like other major and minor cannabinoids, it reacts with the body’s endocannabinoid system and receptors in the central nervous system and immune system.
This less-famous cannabinoid exists as cannabigerolic acid (CBGA) before it is converted to its true form. The mother cannabinoid CBGA is not only a precursor to CBDA, but also to Tetrahydrocannabinolic (THCA) and Cannabicheomenic acid (CBCA) Conversion of CBGA to CBDA CBGA is converted into CBDA by an enzymatic process. Once formed, it remains this way until the decarboxylation process takes place. Decarboxylation is the conversion of acidic cannabinoids to their decarboxylated forms. CBDA is converted to CBD, THCA to THC, and CBCA to CBC. When cannabis is heated, the decarboxylation process takes place. Cannabinoids’ molecular structure changes when they are heated, dried, or treated. The method alters the substance’s chemical structure by removing one acidic carboxyl group.
While certain cannabis plants have been cultivated to contain balanced quantities of CBDA and THCA, CBDA is often only found in very small concentrations in cannabis plants. Mainly hemp plants are well-known for having significant levels of CBDA and traces of THCA.
The cannabinoids found in hemp plants can be concentrated through an extraction procedure. These cannabinoids alter how cells communicate response signals, which can have a variety of positive impacts on the body and mind.
CBDA was first discovered and isolated in 1965 by Israeli scientist Rafael Mechoulam. It was subsequently activated to CBD for its medical benefits. New studies suggest that CBDA could be more effective in its acidic state than CBD for curing or treating some medical conditions. Is CBDA psychoactive? CBDA does not induce any form of psychoactivity. Like CBD, it is unable to cause intoxication. It is often used for medical patients that do not want to feel impaired, couch-locked, or lose focus. CBDA does not bind to the CB1 and CB2 receptors because it is acidic. Instead, it inhibits the Cox-2 enzyme without impacting the CNS. Benefits of CBDA in hemp products CBDA is perceived as an effective treatment for certain medical illnesses. Its affinity to bind to serotonin receptors allows it to affect most symptoms, including mood swings, nausea, fatigue, and inflammation.
Compared to CBD, CBDA has been found to have a stronger activation of 5-HT1A serotonin receptors. Numerous physiological processes, including the control of mood, motion sickness, migraine, and intestinal movement, are influenced by serotonin.
According to the available studies, CBDA’s potential as a medication is still in question. Clinical investigations have mainly utilized animal models up until now. We won’t fully understand CBDA’s potential until clinical trials focus on people’s health and its mechanism of action. Anti-inflammatory effect of CBDA Due to its features as a specific Cox-2 inhibitor, CBDA has anti-inflammatory properties and may be effective in lessening inflammation. The functions of cyclooxygenase (Cox) enzymes 1 and 2 vary.