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When's the best time to get a booster shot? Doctors suggest a six-month interval

Jason Gale, Bloomberg News on

Published in News & Features

Booster shots are rolling out across much of the world to spur protection against COVID-19, prompting questions about when exactly they should be given. While there aren’t clear-cut answers, doctors say there’s a downside to getting them too soon.

It takes time for the immune system to build up its defenses. Following vaccination or a natural infection, cells in the lymph nodes begin to mature and improve so they’re better prepared if they encounter the pathogen again. It takes several months to build what’s known as immune memory — essentially protection galvanized by long-lived, antibody-secreting plasma cells that reside in niches such as the bone marrow.

A booster shot given several months after the immune system has been primed by an initial series — usually two doses of the vaccine — can invigorate its response, said Stanley Plotkin, a veteran vaccinologist and emeritus professor of pediatrics at the University of Pennsylvania in Philadelphia. The additional inoculation triggers a surge of antibodies that are more adept at thwarting a range of SARS-CoV-2 variants, he said.

“That interval could be as short as four months, but generally speaking, a six-month interval is probably best,” said Plotkin, whose pioneering research led to a vaccine for rubella more than 50 years ago.

An even shorter interval, such as two months, could compromise the body’s ability to establish a durable immune response, he said in an interview.

That’s because the immune system needs time to rejuvenate after making antibodies quickly and crudely to a new foe, said John Wherry, director of the institute for immunology at the university’s Perelman School of Medicine. As the “emergency response” dissipates, the body works on making better antibodies that can be amplified rapidly when spurred by either another dose of vaccine or a natural infection.


“A bit of rest seems to improve ‘boostability,’” Wherry said.

So-called neutralizing antibodies that latch onto coronavirus particles and stop them from penetrating healthy cells are critical in defending against COVID-19. They wane months after immunization or a natural infection, however, increasing the risk of a SARS-CoV-2 infection. That’s prompted some health authorities to recommend an extra shot for adults to augment their protection against a winter COVID-19 wave fueled by the hyper-infectious delta variant.

Researchers at Chicago’s Northwestern University found a third dose of either the Pfizer Inc. or Moderna Inc. shot some eight months after the second dose led to a 25-fold increase in antibody levels in a study of 33 healthy adult volunteers.

There’s evidence to suggest that even greater intervals may be helpful, said Miles Davenport, head of the infection analytics program at the University of New South Wales’ Kirby Institute in Sydney. Longer delays between doses of the AstraZeneca Plc shot, and vaccinating COVID-19 survivors at different time points, show the peak immune response may come if a boost is given at least a year after the second dose, he said.


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