UK News - Genes might revolutionize vaccines

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Genes might revolutionize vaccines

SWINDON, England (UPI) -- British scientists say they've determined specialized molecules that activate immune system receptor cells could revolutionize the design and use of vaccines.

Researchers from the Biotechnology and Biological Sciences Research Council -- the United Kingdom's funding agency for life sciences research -- said veterinary scientists have studied a family of genes called toll-like receptors in livestock. They report that those receptors, one of the oldest components of the immune system, can recognize pathogens by their components, activating tailored cellular responses against invading pathogens.

"Animals have co-evolved with most pathogens for millions of years," said Professor Dirk Werling of the Royal Veterinary College, a member of the research team. "We compared TLR gene sequences across a range of mammalian species. We have found evidence that animal immune systems have evolved to recognize pathogens not only in a species-specific manner, but also, pathogens in distinct geographical locations."

The researchers say their findings suggest specific toll-like receptors could be administered along with vaccines to improve the prevention of diseases that have varied immune responses across species. They said that procedure might result in one vaccine preventing a particular disease in all mammals.

The study appears in the journal Business.

Copyright 2009 by United Press International

This news arrived on: 10/22/2009

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